This timely volume explores the unique challenges faced by SM and TGNC clients today. Experts in the field examine how the concepts of gender and sexual orientation are both socioculturally-constructed and can be informed by biologically-focused research, thus setting the stage for flexible, affirmative mental health services. Chapters cover a range of practice-focused as well as theory-based topics, including complexity in identity, minority stress, and stigma management. With concise summaries of research findings and detailed case studies, contributors provide an intersectional understanding of how practitioners can work within rapidly-changing political and legal contexts to uncover and affirm clients’ multiple social identities, and build resilience.