Rodney demands his sister, Dr. Sarah Holloway, share her Nanotechnology breakthroughs to help him lose two hundred pounds. Sarah refuses him saying that it's too dangerous! Her Nanites are designed to improve women's health and are not for men. Rodney arranges a theft from her lab and procures a dose for himself.

He swallows the Nanites and as he loses weight, he also begins to radically change. After the Nanites make Rodney a perfect specimen, he faces a new set of challenges AS A WOMAN!